This family currently (2019) comprises the following genera:
Acanthocladus, Ancylotropis, Atroxima, Badiera, Balgoya, Barnhartia, Bredemeyera, Carpolobia, Comesperma, Diclidanthera, Epirixanthes, Eriandra, Hebecarpa, Heterosamara, Monnina, Moutabea, Muraltia, Nylandtia, Pilostaxis, Polygala, Polygaloides, Pteromonnina, Rhinotropis, Salomonia, Securidaca.